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DÉGRADATION PARTIELLE POST-RÉTICULATION D'HYDROGELS D'AMIDE RÉTICULÉS
专利权人:
Nestlé Skin Health SA
发明人:
申请号:
EP18209081.1
公开号:
EP3659632A1
申请日:
2018.11.29
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention provides a method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules at a concentration Cfinal (mg/mL), said method comprising the steps of: a) crosslinking a glycosaminoglycan having a molecular weight of above 700 kDa in conditions so as to provide a glycosaminoglycan hydrogel crosslinked by amide bonds and having a Cmin (mg/mL) that is above Cfinal/2, wherein Cmin is the concentration of gel-form glycosaminoglycan in the gel when fully swollen in physiological buffer; b) subjecting the hydrogel from step a) to post-crosslinking degradation of the glycosaminoglycan backbone, thereby reducing the Cmin of the hydrogel to a value that is below Cfinal/2; and c) formulating the partially degraded hydrogel obtained from step b) to form an injectable hydrogel composition having a concentration of glycosaminoglycan molecules of Cfinal (mg/mL).
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中国工程科技知识中心
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