The present disclosure provides systems regimens, devices and methods for improving organ function by challenged-exercise, training, and/or education and/or nutritional regimens, or devices intended for improving organ performance, and for prevention and treatment of loss of an effect to exercise regimens in healthy and chronic subjects, or lack of full responsiveness to exercise, training, nutritional or education regimens in subjects who wish to improve the function of their organs, or with chronic diseases. There are provided herein devices, systems, and methods for real time or delayed altering of the parameters of training regimens and/or time of administration and/or combining different exercise, training, nutrition or education regimens, for improving the long term effect of the regimen. According to some embodiments, any training regimen and/or device-generated maneuver/stimulation, wherein the parameters are updated within the exercise regimen/maneuver period, for personalizing the regimen parameters and increasing the accuracy and efficacy of the regimen for achieving the desired physiological goal, and to prevent long-term adaptation for ensuing prolong effect of the training regimen on the target organ function or physiological pathway. Output parameters are continuously, semi continuously, or conditionally being updated based on measurements and inputs provided to a compute circuitry configured to facilitate closed loop machine learning capabilities.La présente invention concerne des systèmes, des régimes, des dispositifs et des procédés pour améliorer la fonction d'organe par des régimes d'exercice soumis à une déficience, d'entraînement et/ou d'éducation et/ou nutritionnels, ou des dispositifs destinés à améliorer les performances d'un organe, et pour la prévention et le traitement de la perte d'un effet sur des régimes d'exercice chez des sujets sains et chroniques, ou un manque de réactivité complète à des régimes d'exercice, d'entraînement, nutriti
