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TETRACYCLIC COMPOSITION
专利权人:
ЧУГАИ СЕЙЯКУ КАБУСИКИ КАЙСЯ (JP)
发明人:
ФУРУМОТО Кентаро (JP),СИРАКИ Кодзи (JP),ХИРАЯМА Томоаки (JP)
申请号:
RU2013112011/04
公开号:
RU2013112011A
申请日:
2011.08.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A composition comprising a substance according to formula (I), a pharmaceutically acceptable carrier and a dissolution aid, wherein all of A, A, A, A, A, A, A and A are C, or any one of A, A, A , A, A, and A is N (provided that when it is N, there is no substituent group for it), and the rest are C; A is selected from NR, O and S; each of R and R is independently [1] a hydrogen atom, [2] a cyano group, [3] a halogen atom or a [4] 4-10 membered heterocycloalkyl group which may be substituted with a 4-10 atom heterocycloalkyl group (s); R is selected from the group consisting of (1) hydrogen atom, (2) C1-6 alkyl group, (3) C1-6 alkenyl group, (4) C1-6 alkynyl group, (5) cyano group, (6) halogen atom, (7) ) (C 1-6 alkyl) amino group which may be substituted by C 1-6 alkylsulfonyl group (s), m2: 0 ~ 2 and (8) nitro groups; R is selected from the group consisting of (1) hydrogen atom, (2) C 1 alkyl group which may be substituted [1] halogen atom (s), [2] hydroxy group (s) or [3] alkoxy group (s), (3) caryl group, (4) cyano group, (5) alkanoyl group, which may be substituted A Caryl group (s), (6) a (C1-6 alkyl) -aminocarbonyl group which may be substituted with one or more R, R: [1] Caryl group, [2] Calkoxy group, [3] 5-14 membered heteroaryl group or [ 4] Sarylsulfonyl group, m3a: 0 ~ 2, (7) hydroxycarbonyl group, (8) alkoxycarbonyl group, which may be substituted by [1] hydroxy group (s) or [2] alkoxy group (s), (9) halogen atom, ( 10) (C1-6alkyl) amino group which may be substituted by Caryl group (s), m3b: 0 ~ 2, (11) C1-6alkylcarbonyl (C1-6alkyl) amino group which may be substituted by [1] Caryl group1. Композиция, содержащая вещество, соответствующее формуле (I), фармацевтически приемлемый носитель и средство, способствующее растворению,гдевсе из A, A, A, A, A, A, Aи Aпредставляют собой C, или любой один из A, A, A, A, Aи Aпредставляет собой N (при условии, что, когда он представляет собой N, для него не существует группы заместителя), а остальные представляют с
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