The present invention concerns antigen binding proteins that bind TL1A, including bispecific antigen binding proteins (e.g., antibodies) to TL1A and TNF-α. Such bispecific antibodies can be in a conventional tetrameric immunoglobulin format, in which one heavy chain-light chain pair of the antibody is directed to TL1A and the other to TNF-α The bispecific antigen binding proteins may also be comprised in a IgG-scFv fusion, in which a conventional tetrameric antibody directed to one antigen is fused to a pair of single chain Fv units directed to the other. The invention further relates to uses of the anti-TL1A binding proteins and anti-TL1A/anti-TNF-α antigen binding proteins, and pharmaceutical formulations thereof.本發明係關於可結合TL1A之抗原結合蛋白,包括針對TL1A及TNF-α之雙特異性抗原結合蛋白(例如抗體)。此種雙特異性抗體可呈習知四聚免疫球蛋白形式,其中該抗體之一個重鏈-輕鏈配對針對TL1A且另一個重鏈-輕鏈配對針對TNF-α。該等雙特異性抗原結合蛋白亦可包含於IgG-scFv融合物中,其中針對一種抗原的習知四聚抗體與針對另一種抗原的一對單鏈Fv單元融合。本發明進一步係關於該等抗TL1A結合蛋白及抗TL1A/抗TNF-α抗原結合蛋白之用途以及其醫藥調配物。
