<;P>;PROBLEM TO BE SOLVED: To provide a composition, food or drink which has an immunoregulatory effect, can easily be taken in daily living, is safe, and little produces side effects. <;P>;SOLUTION: This immunoregulatory composition contains super oxide dismutase (SOD) originated from a melon extract as an active ingredient. The composition can be used for inhibiting or improving the advance of autoimmune disease or a state related thereto. <;P>;COPYRIGHT: (C)2008,JPO&INPIT