Roger John Taylor;Lee Edwards;Emma Budd;Kamlesh Jagdis Bala;Catherine Howsham;Darren Mark LeGrand
发明人:
Kamlesh Jagdis Bala,Emma Budd,Lee Edwards,Catherine Howsham,Darren Mark LeGrand,Roger John Taylor
申请号：
US14345022
公开号：
US20140323485A1
申请日:
2012.09.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A compound of Formula Iand pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Ra, A, B, D and E are all as defined herein. The compounds modulate the activity of CFTR and are useful in the treatment of inflammatory or obstructive airways diseases or mucosal hydration, including, for example cystic fibrosis. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
