A method for increasing expression of NOS3 gene, increasing expression of PLAT gene, decreasing expression of F3 gene and/or decreasing expression of SERPINE1 gene is provided, wherein the method comprises administering to a subject in need an effective amount of a Chenopodium formosanum extract. Accordingly, the method is effective in treating or preventing diseases associated with NOS3 gene, PLAT gene, F3 gene and/or SERPINE1 gene.