< Topic >The prevention of COPD or the asthma and/or the medicine constituent which contains useful chemical compound and particular chemical compound in remedy as the active ingredient is offered.SolutionsAs for these inventors, ardency kuromobakuteriumu which was picked in the result and Tokyo Okutama Cho which were examined (Chromobacterium) the annular depushipepuchido chemical compound of being attached soil bacterial origin, unites the windpipe contractile depressant action and the inflammation depressant action of the windpipe concerning the pharmacology operation of fermentation natural ones, knowledge doing that it is effective as a preventive of COPD or the asthma or remedy medicine, you completed this invention. Namely, this invention contains annular depushipepuchido chemical compound or that salt as the active ingredient, it is something which is prescribed by the dosage, dot point dosage or inhalation dosage inside the windpipe, the chronic blockade Characteristic lung disease (COPD) or prevention of the asthma and/or regards the medicine constituent for remedy.< Choice figure >It is not【課題】COPD又は喘息の予防及び/又は治療に有用な化合物並びに当該化合物を有効成分として含有する医薬組成物を提供する。【解決手段】本発明者らは、醗酵天然物の薬理作用について鋭意検討した結果、東京都奥多摩町で採取したクロモバクテリウム(Chromobacterium)属の土壌細菌由来の環状デプシペプチド化合物が、気道収縮抑制作用と気道の炎症抑制作用を併せ持ち、COPD又は喘息の予防若しくは治療剤として有効であることを知見して、本発明を完成した。即ち、本発明は、環状デプシペプチド化合物又はその塩を有効成分として含有し、気管内投与、点鼻投与又は吸入投与により投与されるものである、慢性閉塞性肺疾患(COPD)又は喘息の予防及び/又は治療用医薬組成物に関する。【選択図】なし
