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AN IMPROVED PROCESS FOR THE PREPARATION OF AMORPHOUS ATORVASTATIN CALCIUM.
专利权人:
发明人:
KHAMAR BAKULESH MAFATLAL,PRABHAKAR MOTIRAM TEKADE,SIDDIQUI ISHRAT HUSSAIN,BAPAT UDAY RAJARAM,MODI INDRAVADAN AMBALAL
申请号:
IN463/MUM/2010
公开号:
IN2010MU00463A
申请日:
2010.02.19
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
The present invention relates to an improved process for preparation of Atorvastatin calcium in amorphous form. Tine invention also reates to an improved process for the preparation of amorphous atorvastatin calcium comprising: reaction of (βR,ỡR)-2-(4-fuorophenyl)-β-ỡ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyI amino) carbonyl-1H-Pyrrole-1-heptanoic acid t-butyl ester {formula II) in an organic water immiscible solvent with aqueous alkali to give an alkali metal salt of atorvastatin which is then converted to Atorvastatin calcium by treating with calcium source.
来源网站:
中国工程科技知识中心
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