The present disclosure provides isolated monoclonal antibodies that specificallybind to CXCR4 with high affinity, particularly human monoclonal antibodies.Nucleic acid molecules encoding the antibodies of this disclosure, expressionvectors, host cells and methods for expressing the antibodies of this disclosureare also provided. Immunoconjugates, bispecific molecules and pharmaceuticalcompositions comprising the antibodies of this disclosure are also provided.This disclosure also provides methods for detecting CXCR4, as well as methodsfor treating various cancers, inflammatory disorders and HIV infection usingan anti-CXCR4 antibody of this disclosure.
