Itochu Chemical Frontier Corporation;Oishi Koseido Co., Ltd.
发明人:
Tatsuya Mori,Naoyuki Saida
申请号：
US15646744
公开号：
US09931403B2
申请日:
2017.07.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass % of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.
