KLAUS WENING,ANJA GEIßLER,JANA DENKER,LUTZ BARNSCHEID
申请号：
US15823918
公开号：
US20180078544A1
申请日:
2017.11.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant； wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant； wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles； wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles； and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.
