The present invention provides methods and compositions for treating hepatocellular carcinoma (HCC) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating HCC comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent, such as an agent that inhibits microtubule disassembly.本發明提供治療肝細胞癌(HCC)之方法及組合物,該治療係投與包含包括紫杉烷與白蛋白之奈米顆粒的組合物。本發明亦提供治療HCC之組合療法,其包含向個體投與有效量之包含包括紫杉烷與白蛋白之奈米顆粒的組合物,及另一藥劑,諸如抑制微管拆卸之藥劑。(無元件符號說明)