Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.本發明提供(例如)用於治療免疫與發炎病症(包括腫瘤及癌症)之調節細胞激素活性的方法。本發明亦提供投與IL-33及IL-33受體之激動劑或拮抗劑之方法。