CHINESE ACADEMY OF SCIENCES;SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY
发明人:
Jing WANG,Min GUO,Pengfei FANG,Biao YU
申请号：
US16627144
公开号：
US20200129490A1
申请日:
2018.06.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided is the use of an aromatic ring drug in inhibiting a key transcription factor of malignant melanoma. In particular, provided is the use of a compound as represented by formula A, or an optical isomer thereof or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof in the preparation of a pharmaceutical composition or preparation. The pharmaceutical composition or preparation is used for: (a) inhibiting a key transcriptional regulatory factor of malignant melanoma, namely MITF (Microphthalmia-associated Transcription Factor)； (b) treating MITF-related diseases such as melanoma, pancreatic cancer, skin hypersensitivity and asthma； and (c) regulating physiological activities in which MITF is involved, such as skin whitening. In the formula, each group is as defined in the description.
