TERRETT, JONATHAN A.,泰瑞强纳森Ａ,泰瑞強納森Ａ,POGUE, SARAH L.,波吉莎拉Ｌ,TOY, KRISTOPHER,托以可里斯多福,YANG, LAN,杨岚,楊嵐,RAO-NAIK, CHETANA,拉欧那克戚他那,拉歐那克戚他那,CHEN, BINGLIANG,陈斌亮,陳斌亮,泰瑞强纳森A,泰瑞強納森A,波吉莎拉L
申请号：
TW097137770
公开号：
TWI446922B
申请日:
2008.10.01
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.本揭露提供以高親合力專一性結合間皮素的單離單株抗體，特別係人類單株抗體。抗體較佳係結合人類間皮素。某些實施例中，抗體能夠內化進入表現間皮素之細胞或能夠介導抗原依賴型細胞毒性。本發明進一步提供能夠抑制間皮素結合卵巢癌抗原CA125之抗-間皮素抗體。亦提供編碼此揭露之抗體的核酸分子、表現此揭露之抗體的表現載體、宿主細胞與方法。亦提供構成此揭露之抗體的抗體-夥伴分子接合體、雙專一性分子與藥學組合物。此揭露亦提供利用此揭露之抗-間皮素抗體偵測間皮素的方法以及治療癌症(諸如，間皮瘤、胰臟癌與卵巢癌)的方法。
