The present invention relates to a pharmaceutical composition comprising a peptide inhibiting the toll-like receptor (TLR) signaling pathway as an active ingredient for preventing or treating lupus. The pharmaceutical composition according to the present invention effectively regulates factors associated with lupus symptoms in a lupus mouse model and as such, is effective for preventing or treating lupus.La présente invention concerne une composition pharmaceutique comprenant un peptide inhibant la voie de signalisation du récepteur de type toll (TLR) en tant que principe actif pour prévenir ou traiter le lupus. La composition pharmaceutique selon la présente invention régule efficacement des facteurs associés aux symptômes du lupus dans un modèle de lupus chez la souris et, en tant que tel, est efficace pour prévenir ou traiter le lupus.본 발명은 TLR(Toll-like receptor) 신호전달 경로를 억제하는 펩타이드를 유효성분으로 포함하는 루푸스 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 약학적 조성물은 루푸스 마우스 모델에서 루푸스 증상 관련 인자들을 효과적으로 조절하므로, 루푸스를 예방 또는 치료하는데 유용하다.