LIPOPHILIC DIESTERS OF CHELATING AGENT AND USES THEREOF FOR THE PREPARATION OF MEDICAMENTS FOR THE INHIBITION OF PROTEASE ACTIVITY

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专利权人:

D-PHARM LTD.

发明人:

申请号：

IL16740605

公开号：

IL167406A

申请日:

2005.03.13

申请国别(地区):

IL

年份:

2012

代理人:

摘要：

The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N&prime；,N&prime；-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.

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