JOHN LATHAM,LEON GARCIA-MARTINEZ,ANNE ELISABETH CARVALHO JENSEN,KATIE OLSON,BEN DUTZAR,ETHAN OJALA,BRIAN KOVACEVICH,JEFFREY T. L. SMITH
申请号：
PT08756095
公开号：
PT2164514T
申请日:
2008.05.21
申请国别(地区):
PT
年份:
2017
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
