The invention relates to a mascara with a high wax content containing an association of elastic polyurethane microspheres and non-compressible and non-porous polymethylsilsesquioxane microspheres. The mascara is packaged in a container provided with flexible parts that can be deformed by manual pressure so as to mix the formula. The invention also relates to a method for applying make-up to eyelashes, using said composition and packaging.