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Glucagon-like peptides-1 analogs and their use
专利权人:
ЧЖЭЦЗЯН БЕТА ФАРМА ИНК. (CN)
发明人:
ВАН Иньсян (CN),ТАНЬ Феньлай (CN),ХУ Шаоцзин (CN),ЧЖАО Сяндун (CN),МА Цуньбо (CN),ВАН Яньпин (CN),ШЭНЬ Сяоянь (CN),ДИН Лемин (CN),ХУ Юньянь (CN),ЦАО Хун (CN),ЛУН Вэй (CN)
申请号:
RU2012150108/04
公开号:
RU2012150108A
申请日:
2011.04.29
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A compound of formula I or a pharmaceutically acceptable salt, solvate, chelate, non-covalent complex, prodrug or mixture of any of these compounds, wherein X is glycine or glycinamide. 2. A pharmaceutical composition comprising a therapeutically effective amount of at least one of the compounds of claim 1 and at least one pharmaceutically acceptable excipient. The use of the pharmaceutical composition according to claim 2 for the manufacture of a medicament. 4. The use of the pharmaceutical composition according to claim 3 for the preparation of a medicament for the treatment or prevention of type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, X syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiac vascular disease, stroke, inflammatory bowel disease and / or dyspepsia or stomach ulcers. 5. The use of the pharmaceutical composition according to claim 3 for the preparation of a medicament for inhibiting or preventing the development of type II diabetes. The use of the pharmaceutical composition according to claim 3 for the preparation of a medicament for reducing food intake, decreasing β-cell apoptosis, increasing the functional activity of β-cells, increasing the mass of β-cells and / or for restoring the sensitivity of β-cells to glucose. The use of the compound of claim 1 for the preparation of a medicament for the treatment or prevention of type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, X syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, ischemic bo�1. Соединение формулы Iили их фармацевтически приемлемая соль, сольват, хелат, нековалентный комплекс, пролекарство или смесь любого из указанных соединений;где X - это глицин или глицинамид.2. Фармацевтическая композиция, содержащая терапевтически эффективное количество по меньшей мере одного из соединений по п.1 и по меньшей мере один фармац
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