The method of solubility producing a pharmaceutical suspension comprising ("API") smaller active pharmaceutical ingredients, to prepare a first solution containing a solvent and (a) carboxyl-containing vinyl polymers (b) first By the solution was added under high shear mixing conditions to compounds of the API is soluble in the solvent, and mixed over a period of about 5 hours, from about 5 minutes to, suspended particles of the API in a composition comprising a carboxy-containing vinyl polymers How concentration of API contained in the suspension is greater than the solubility of the API in a solvent include an operation for producing the suspension. Suspension in accordance with the present invention, was produced by such a method is also provided.溶解度が小さな活性医薬成分(“API”)を含む医薬懸濁液を製造する方法であって、(a)カルボキシ含有ビニルポリマーと溶媒を含む第1の溶液を調製し;(b)第1の溶液に、溶媒に溶けるAPIの化合物を高剪断混合条件下で添加し、約5分間~約5時間の時間にわたって混合することにより、カルボキシ含有ビニルポリマーを含む組成物にAPIの粒子を懸濁させた懸濁液を製造する操作を含んでいて;その懸濁液に含まれるAPIの濃度が、溶媒へのそのAPIの溶解度よりも大きい方法。本発明により、このような方法で製造された懸濁液も提供される。
