KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;한국생명공학연구원
发明人:
JUNG, Juyeon,정주연,CHUNG, Bong Hyun,정봉현,KIM, Hye Ran,김혜란,BAE, Pan Kee,배판기
申请号：
KRKR2015/004638
公开号：
WO2015/174694A1
申请日:
2015.05.08
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a composition for cancer diagnosis and treatment using a Leucine zipper pair (ZR/ZE) and, more specifically, to a composition for cancer diagnosis and treatment, capable of selectively treating cancer after cancer diagnosis, wherein the composition comprises: a fusion protein for cancer diagnosis in which an antibody specific to a cancer cell surface receptor is fused to a ZR peptide； and a nano-emulsion for cancer treatment containing a ZE peptide fixed to a surface thereof and a gene or drug for cancer treatment therein. The composition for cancer diagnosis and treatment of the present invention can detect only particular cancer cells by using the fusion protein for cancer diagnosis in which an antibody specific to a cancer cell surface receptor is fused to a ZR peptide, and can deliver a therapeutic material to only the particular cancer cells through a ZR/ZR Leucine zipper pair bond of the fusion protein and the nano-emulsion for cancer treatment containing a ZE peptide fixed to a surface thereof. Further, the composition of the present invention allows multi-image analysis by fixing a fluorescent material to the fusion protein or nano-emulsion, and thus can be favorably used to develop effective diagnostic and therapeutic agents for cancer diseases of breast cancer, liver cancer, pancreatic cancer, brain cancer, stomach cancer, lung cancer, esophageal cancer, colon cancer, prostate cancer, renal cancer, ovarian cancer, and the like.La présente invention concerne une composition pour le diagnostic et le traitement d'un cancer utilisant une paire à fermeture éclair à leucines (ZR/ZE) et, plus particulièrement, une composition pour le diagnostic et le traitement d'un cancer, capable de traiter sélectivement un cancer après le diagnostic du cancer, la composition comprenant : une protéine hybride pour le diagnostic du cancer dans laquelle un anticorps spécifique à un récepteur de surface de cellules cancéreuses est fusionné à un pep
