According to some embodiments, a method of evaluating an extent of intraductal disease in a breast of a subject comprises identifying a target duct of the breast of a subject, wherein the target duct comprises or is likely to comprise at least one abnormality, accessing the target duct through a corresponding ductal orifice of the breast using at least one access device, delivering a volume of a fluid within the target duct and imaging the breast using an imaging device to visualize and evaluate the extent of intraductal disease of the target duct.
