BANHAM, ALISON HILARY,HARRIS, ADRIAN LLEWELLYN,HANDFORD, PENELOPE ANN,LEA, SUSAN MARY
申请号：
CA2897869
公开号：
CA2897869A1
申请日:
2014.01.15
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides antibodies which bind to the Delta/Serrate/LAG-2 consensus sequence (DSL) domain of human Jagged 1 via novel epitopes comprising the residue E228, and inhibit the interaction between human Jagged 1 and its associated receptors. Said antibodies may be administered therapeutically in the treatment of tumours/cancer, preferably those associated with tumoural Jagged 1-mediated signalling and tumour microenvironmental processes in which Jagged 1 and/or Notch-mediated signalling has been implicated, including those comprising Jagged 1-mediated cross talk between the tumour and the tumour microenvironment. The present invention also provides pharmaceutical compositions comprising said antibodies, uses of said antibodies in therapy, hybridomas comprising and/or secreting said antibodies and cells or cell lines expressing said antibodies and humanised/deimmunised variants in recombinant form.
