Yale University;The United States Government as Represented by the Department of Veteran Affairs
发明人:
James E. Hansen,Richard H. Weisbart,Philip W. Noble
申请号：
US16280906
公开号：
US20190307883A1
申请日:
2019.02.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Cancer cells with defects in DNA repair are highly susceptible to DNA-damaging agents, but delivery of therapeutic agents into cell nuclei can be challenging. A sub-set of autoantibodies having nucleolytic activity are capable of nuclear penetration. These antibodies can be used as therapeutic agents targeted towards DNA repair-deficient malignancies.
