A cassette for operatively connecting administration set tubing to an infusion pump includes a thumb tab having a thumb surface and a tubing connector having an in line occluder spaced laterally from the thumb tab. The cassette is configured such that a user s hand will cradle the cassette by pressing a thumb of the user s hand against the thumb surface and wrapping at least one finger of the user s hand around and under the thumb tab whereby a user may apply pressure to tubing connected to the tubing connector at a location corresponding to the in line occluder in a direction generally opposite to a direction in which the thumb is pressed against the thumb surface thereby bypassing the in line occluder and allowing flow through the tubing.
