Deborah L. Mortensen;Paul J. Fielder;Yves Dubaquie;Henry B. Lowman
发明人:
Yves Dubaquie,Paul J. Fielder,Henry B. Lowman,Deborah L. Mortensen
申请号:
US11512046
公开号:
US08097587B2
申请日:
2006.08.28
申请国别(地区):
US
年份:
2012
代理人:
摘要:
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.