The present invention provides the manufacturing method of medicinal preparation for oral administration,For what outermost layer, the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are set,The peripheral part of first water-swellable gel-forming layer and the peripheral part of the second water-swellable gel-forming layer are to engage directly or via adhesion agent layer and form interior packet portion,By the enclosed institute of drug at medicinal preparation for oral administration manufacturing method,The manufacturing method includes the step of forming the first water-swellable gel-forming layer (a),The setting section of what water-swellable gel-forming layer forms the step of recess portion (b),The step of filling drug in the formed recess portion of what and obtaining drug obturator (c),And on what drug obturator,Directly or via adhesion agent layer,The second water-swellable gel-forming layer is formed,The step of peripheral part of coupling recess (d)； And its method for continuous production. The manufacturing method of medicinal preparation for oral administration according to the present invention,, the loss of no drug few by the deterioration of the thermal history of drug, the limitation of no drug additive amount can efficiently be manufactured, drug is fully covered, and the worried medicinal preparation for oral administration of bitter taste or stink of the Shi Buwei from drug is taken.本發明提供口服藥劑之製造方法，為於最外層設置第一水膨潤性凝膠形成層及第二水膨潤性凝膠形成層，第一水膨潤性凝膠形成層的周緣部及第二水膨潤性凝膠形成層的周緣部為直接或經由接著劑層接合而形成內包部，將藥物封入所成之口服藥劑之製造方法，該製造方法具有：形成第一水膨潤性凝膠形成層的步驟(a)，於水膨潤性凝膠形成層的設定部分形成凹部的步驟(b)，於所形成凹部內填充藥物而獲得藥物填充體的步驟(c)，以及於藥物填充體上，直接或經由接著劑層，形成第二水膨潤性凝膠形成層，接合凹部的周緣部的步驟(d)；以及其連續製造方法。根據本發明之口服藥劑之製造方法，可有效率地製造藉由藥物的熱經歷的劣化少，無藥物的損失，無藥物添加量的限制，藥物被完全地遮蔽，服用時不為源自藥物的苦味或臭味所煩惱的口服藥劑。
