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Trypsin-like serine protease inhibitors, and their preparation and use
专利权人:
THE MEDICINES COMPANY (LEIPZIG) GMBH
发明人:
JELAKOVIC STJEPAN,SCHWEINITZ ANDREA,HEROLD PETER,REICHELT CLAUDIA,LUDWIG FRIEDRICH-ALEXANDER,SCHULZE ALEXANDER,DAGHISH MOHAMMED
申请号:
NZ60152111
公开号:
NZ601521A
申请日:
2011.01.28
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
The disclosure provides compounds that are effective as inhibitors of trypsin-like serine proteases, such as human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The disclosure further provides methods of making and using the compounds. the compounds of the disclosure are dipeptides which include non-naturally occurring amino acids.
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