Seung Su Kim,Se Young Lim,Sung Youb Jung,Se Chang Kwon
申请号：
US14369436
公开号：
US20140377290A1
申请日:
2012.12.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to a glucagon-like peptide-2 (GLP-2) conjugate comprising native GLP-2 or its derivative and an immunoglobulin Fc fragment being covalently linked via a non-peptidyl polymer, wherein the native GLP-2 or its derivative has a thiol group introduced at its C-terminal end, and one end of the non-peptidyl polymer is linked to an amino acid residue of the GLP-2 other than the N-terminal amino group thereof； a method for preparing the GLP-2 conjugate； a pharmaceutical composition comprising the same； and a method for treating or preventing intestinal disease, intestinal injury, or gastrosia by using the same. Since the GLP-2 conjugate of the present invention has a remarkably increased binding affinity to a GLP-2 receptor, it shows a prolonged in vivo half-life and an improved in vivo durability and stability.
