The local patch which contains the kapusaishin or kapusaishin similar substance, the production method and its use. As for this invention, here, as for the said matrix the liquid micro reservoir which is based on the parents crocking characteristic solvent is contained in regard to the local patch which includes with the polysiloxane based self adhesiveness matrix which contains the remedy chemical compound which resembles to bearing stratum and kapusaishin or kapusaishin of remedy chemical compound - impermeability and before the using the protective film which is removed, the said remedy chemical compound in the said micro reservoir exists with complete melting form, and density of the said remedy chemical compound in the said micro reservoir drop is smaller than solubility. As for this invention furthermore, the production method, and nervous obstacle characteristic it regards the use in painfully remedying.カプサイシン又はカプサイシン類似物質を含有する局所パッチ、その製造方法及びその使用。本発明は、治療化合物-不透過性の支持層と、カプサイシン又はカプサイシンに類似した治療化合物を含有するポリシロキサン・ベースの自己接着性マトリックスと、使用前に取り外される保護フィルムとを含む局所パッチに関し、ここで、該マトリックスは両親媒性溶剤に基づく液体マイクロリザーバを含有し、該治療化合物は該マイクロリザーバ中に完全な溶解形態で存在し、そして該マイクロリザーバ小滴中の該治療化合物の濃度は飽和濃度より小さい。本発明は更に、その製造方法、及び神経障害性疼痛の治療におけるその使用に関する。
