COMPOSES DE 5-[(HETERO)ARYLE MONOCYCLIQUE SUBSTITUE-1,2,4-OXADIAZOL-3-YL]-( HETEROARYLE CONDENSE SUBSTITUE) ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DU RECEPTEUR S1P1
[Problems]To provide a useful compound as an active ingredient for a preventive and/ortreatingagent for rejection in the transplantation of an organ, bone marrow, or atissue, an autoimmunedisease, or the like, which has an excellent S1P1 agonist activity.[Means for solving]Since the compound of the invention has an S1P1 agonist activity, it is usefulas an activeingredient for a treating or preventing agent for a disease caused byunfavorable lymphocyticinfiltration, for example, an autoimmune disease such as graft rejection inthe transplantation ofan organ, bone marrow, or tissue or graft-versus-host disease, rheumaticarthritis, multiplesclerosis, systemic lupus erythematosus, a nephrotic syndrome,encephalomeningitis, myastheniagravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder,asthma, atopic dermatitis,inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, oran inflammatorydisease, and further, a disease caused by the abnormal growth or accumulationof cells such ascancer or leukemia.(see formula I)
