plasminogen and plasmin variants

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专利权人:

THROMBOGENICS NV

发明人:

RICHARD REINIER ZWAAL

申请号：

BR112013017172

公开号：

BR112013017172A2

申请日:

2012.01.04

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatylic destruction of the protease activity plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.

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