MARÍA DEL CARMEN, ABRAHANTES PÉREZ,MANUEL SELMAN-HOUSEIN SOSA,RAÚL GÓMEZ RIERA,JORGE VICTOR GAVILONDO COWLEY,JESÚS REYES GONZÁLEZ,GLORIA VÉLIZ RÍOS,EDUARDO MARTÍNEZ DÍAZ,CARIDAD ANAIS GASMURI GONZÁLEZ
申请号：
MYPI 20053102
公开号：
MY150858A
申请日:
2005.07.07
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION IS RELATED TO A COMPOSITION CAPABLE OF INHIBITING THE GROWTH OF TUMORAL CELLS OF DIFFERENT HISTOLOGICAL ORIGINS AND OF ACTIVATED ENDOTHELIAL CELLS. THE COMPONENTS OF SAID COMPOSITIONS ARE POLYPEPTIDE FRAGMENTS OF THE SERRALYSINS, CORRESPONDING TO THE C-TERMINAL FRAGMENT, FROM THE INTERNAL METIONINE TROUGH THE END OF THE MOLECULE, WHICH COULD BE COMBINED AMONG THEM AND OPTIONALLY WITH THE PRODIGIOSINS THAT POTENTIATE THE ANTI-TUMORAL EFFECT OF THE COMPOSITION. THE PRODIGIOSINS IN THE COMPOSITION COULD BE AT A CONCENTRATION OF 0.1 - 100 NM. THE ANTI-PROLIFERATIVE ACTION OF THIS COMPOSITION IS MEDIATED BY APOPTOTIC MECHANISM. IT'S "IN VIVO" ADMINISTRATION HAS ANTI-TUMORAL, ANTIANGIOGENIC AND PROTECTIVE EFFECT AGAINST MALIGNANT TUMORS.
