B7 family member zB7H6 and related compositions and methods

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专利权人:

インコーポレイテッド;ザイモジェネティクス, インコーポレイテッド;ザイモジェネティクス，

发明人:

キャメロン・エス・ブラント,ジェイコブ・ジェイ・ケネディー,スー・ウェンフェン,ユージーン・シー・イー,ブライアン・エー・フォックス,ツェーレン・ガオ,パラブアー・ブイ・シバクマール

申请号：

JP2013196500

公开号：

JP5887320B2

申请日:

2013.09.24

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies, as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/