ABSTRACT PHARMACEUTICAL FORMULATIONS FOR THE PROLONGED RELEASE OF ACTIVE PRINCIPLE(S), AND THEIR APPLICATIONS, ESPECIALLY THERAPEUTIC APPLICATIONS The present invention relates to novel pharmaceutical formulations based on aqueous colloidal suspensions for the prolonged release of one or more active principles - AP - particularly protein and peptide active principles, and to the applications, especially therapeutic applications, of these formulations. This formulation comprises an aqueous colloidal suspension of low viscosity based on micrometric particles of a water-soluble, biodegradable, amphiphilic polymer PC carrying hydrophobic groups (GH) - alpha-tocopherol -and ionizable hydrophilic groups (GI) - Glu - that are at least partially ionized, said particles being capable of associating spontaneously and non-covalently with an AP, at pH = 7.0, under isotonic conditions, and having a size of between 0.5 and 100 )a.m. This suspension contains multivalent ions (Mg^"*^) of opposite polarity to where n is the valency of said multivalent ions, [IM] is the molar concentration of multivalent ions, [GI] is the molar concentration of ionizable groups GI, being between 0.3 and 10.
