A novel free-breathing myocardial T2* mapping combining multiple single-shot black-blood GRE-EPI images with automatic non-rigid motion correction. The present disclosure describes a method of accurate myocardial T2* measurements that is insensitive to respiratory motion, and is likely to reduce sensitivity to arrhythmia as well since each image is acquired in a single heart beat. The T2*-weighted GRE-EPI images are motion corrected using, e.g., automatic non-rigid motion correction to reduce mis-registration due to respiratory motion. A T2* map is calculated using the motion-corrected T2*-weighted images by fitting pixel intensities to a, e.g., two-parameter mono-exponential model.
