Nigel John Brunskill,Gregory A. Demopulos,Tom Dudler,Hans-Wilhelm Schwaeble
申请号:
US15399524
公开号:
US20170189525A1
申请日:
2017.01.05
申请国别(地区):
US
年份:
2017
代理人:
摘要:
In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.