ECKELMAN, Brendan P.,KAPLAN, Michael D.,WILLIS, Katelyn M.,TIMMER, John C.
申请号：
AU2019251488
公开号：
AU2019251488A1
申请日:
2019.04.10
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, components of the multispecific polypeptides are connected by a non-cleavable linker. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
