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3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
专利权人:
SANOFI
发明人:
COTE-DES-COMBES, Sylvain,FROISSANT, Jacques,GIBERT, Jean-François,MARGUET, Frank,PACAUD, Christophe,PUECH, Frédéric,RAVET, Antoine
申请号:
TN2012000520
公开号:
TN2012000520A1
申请日:
2012.10.31
申请国别(地区):
TN
年份:
2014
代理人:
摘要:
Compounds corresponding to the general formula (I) in which R2 represents a group C1-10-alkyl, C3-10- cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl- C3-7-cycloalkyl, C3-7-cycloalkyl-C3-7-cycloalkyl, C1-6- alkylthio-C-1-10-alkyl, C1-6-alkoxy-C1-10-alkyl, hydroxy- C1-10-alkyl, hydroxy-C1-6-alkyl-C3-7-cycloalkyl-C1-6-alkyl, hydroxy-C3-10-cycloalkyl, C1-10-fluoroalkyl or C3-10- fluorocycloalkyl; an optionally substituted heterocyclic group; a group C1-10-alkyl substituted with an optionally substituted heterocyclic group; Xe represents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-fluoroalkyl or cyano; and R7 represents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents, in the form of the base or of an acid-addition salt. Therapeutic use.
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