HLA-DR CAR-T COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME

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专利权人:

Ltd.;Eutilex Co.

发明人:

Byoung S. Kwon,Chungyong Han

申请号：

US16485598

公开号：

US20200165342A1

申请日:

2018.02.21

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided are CAR-T compositions that are directed to HLA-DR. Certain provided HLA-DR CAR compositions exhibit low affinity for a polymorphic region of HLA-DR of a subject. Various in vitro and in vivo methods and reagents related to HLA-DR CAR-T are also provided. Methods described herein can include, for example, characterization of HLA-DR binding, proliferation of T-cells, as well as prevention and/or therapeutic treatment of cancer using a HLA-DR CAR-T composition provided herein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/