COUPLEUR D'ANTIGÈNES DE LYMPHOCYTES T À MUTATION Y182T ET PROCÉDÉS ET UTILISATIONS DE CELUI-CI

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专利权人:

Mcmaster University

发明人:

申请号：

EP18867125.9

公开号：

EP3694997A1

申请日:

2018.10.12

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/