LINDA C. BURKLY,JANINE L. FERRANT-ORGETTAS,ELLEN A. GARBER,YEN-MING HSU,LIHE SU,FREDERICK R. TAYLOR,RALPH ADAMS,DEREK THOMAS BROWN,ANDREW GEORGE POPPLEWELL,MARTYN KIM ROBINSON,ANTHONY SHOCK,KERRY LOUI
申请号：
BRPI0809042
公开号：
BRPI0809042A2
申请日:
2008.03.21
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
This invention provides binding proteins, including antibodies, antibody derivates and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivate or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
