Judith Del Campo Ascarateil,Imene Turki Hani,Fergal Hill
申请号：
US14570133
公开号：
US09388225B2
申请日:
2014.12.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present application is related to a modified protein comprising a protein having a coiled coil domain and a peptide having the sequence such as shown in SEQ ID NO 1: ZXBBBBZ that is linked to the coiled coil domain wherein:Z is any amino acid or is absentX is any amino acidB is an arginine (R) or a lysine (K).Said modified protein is in particular an antigen or a carrier protein, associated to an antigen. This modified protein has an increased affinity for negatively charged polymers such as nucleic acids or heparin, and shows an increased immunogenicity.
