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Methods and compositions for specific modulation of MCL-1
专利权人:
Dana-Farber Cancer Institute; Inc.
发明人:
Loren D. Walensky,Michelle L. Stewart
申请号:
US14713379
公开号:
US09505816B2
申请日:
2015.05.15
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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