The present invention relates to a method of manufacturing a quarantine packaging box capable of real-time verification of a quarantine maintenance state, and in detail, (a) an indicator that changes color in response to the pH of a disinfectant for disinfection on the paper surface of the packaging box 101 (indicator) coating so that the impregnation (含浸)； (b) drying the application surface 102 of the indicator； (C) inserting the contents to be packaged in the packaging box 101 to seal； (d) In the packaging box 101, the label (103) for the control color of the indicator response color (H) (normal prevention indication color (h1), weak prevention indication color (h2), and defective prevention indication color (h3)) Attaching； (e) applying an antiseptic disinfectant to the surface of the packaging box 101； (f) the indicator reaction color (H) of the disinfectant coating surface 104 is inspected and shipped to check whether it matches the normal discharge display color (h1) of the label (103) for verification. According to the present invention, the handling (packaging, transportation, delivery, and consignee) of the packaging box 101 for quarantine is indicated by the normal response of the indicator reaction color (H) of the packaging box 101 and the label 103 for the control color inspection. By comparing and checking the color (h1), it is possible to always check the quarantine maintenance state of the packaging box 101 in real time, and thus has the feature of preventing the spread of infectious diseases due to the packaging box 101 being handled.본 발명은 방역유지상태의 실시간 검증이 가능한 방역용 포장상자의 제조방법에 관한 것으로, 상세하게는 (a) 포장상자(101)의 종이표면에 방역용 소독제의 pH에 반응하여 색상이 변하게 하는 지시약(indicator)이 함침(含浸)되도록 도포하는 단계； (b) 상기 지시약 도포면(102)을 건조시키는 단계； (c) 상기 포장상자(101)에 포장할 내용물을 삽입하여 봉합하는 단계； (d) 상기 포장상자(101)에 지시약반응색상(H)의 대조색(정상방역표시색(h1), 약한방역표시색(h2), 불량방역표시색(h3)) 검사용 라벨(103)을 부착하는 단계； (e) 상기 포장상자(101)의 표면에 방역용 소독제를 도포하는 단계； (f) 상기 소독제 도포면(104)의 지시약반응색상(H)이 검증용 라벨(label)(103)의 정상방역표시색(h1)과 일치하는지 검사하
