Lezberg, Paul,Hassanein, Waleed,Elbetanony, Ahmed,Sousa, Dennis,Khayal, Tamer,Hansen, Elizabeth,Cecere, Giovanni
申请号：
AU2008260409
公开号：
AU2008260409B2
申请日:
2008.04.24
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention provides, in various embodiments, systems, devices and methodsrelating to ex-vivo organ care. In certain embodiments, the invention relatesto maintaining an organ ex- vivo at near-physiologic conditions. The presentapplication describes a method for using lactate measurement in the arterialand the venous blood lines of the Organ Care System Heart perfusion device to evaluatethe: 1) The overall perfusion status of an isolated heart and 2) The metabolicstatus of an isolated heart and 3) the overall vascular patency of an isolateddonor heart. This aspect of the present invention uses the property of myocardialcell's unique ability to produce/generate lactate when they are starvedfor oxygen and metabolize/utilize lactate for energy production when they arewell perfused with oxygen.
