JOHN CHADDOCK,PATRICK STANCOMBE,AIMEE COSSINS,IAN BIRCH-MACHIN,MATTHEW BEARD
申请号：
PT09785502
公开号：
PT2326665E
申请日:
2009.08.19
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
The present invention relates to fusion proteins comprising a non-cytotoxic protease and a EGF mutein ligand. The EGF mutein provides improved EGF receptor activation for the claimed fusion proteins. Also provided is the use of said polypeptides as therapeutics for suppressing mucus hypersecretion, inflammation, endocrine neoplasia and/or neuroendocrine disorders, neuroendocrine tumors, for suppressing cancers such as colorectal cancer, prostate cancer, breast cancer, and lung cancer.
