COTTONE, ROBERT JOHN, JR.,ROWLAND, STEPHEN M.,PARKER, SHERRY,YOKLAVICH, MEG,KUTRYK, MICHAEL JOHN BRADLEY
申请号：
CA2626805
公开号：
CA2626805C
申请日:
2006.11.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A medical device for implantation into vessels or luminal structures withinthe body is provided, which stimulates positive blood vessel remodeling. Themedical device, such as a stent and a synthetic graft, is coated with apharmaceutical composition consisting of a controlled-release matrix and oneor more pharmaceutical substances for direct delivery of drugs to surroundingtissues. The coating on the medical device further comprises a ligand such asa peptide, an antibody or a small molecule for capturing progenitorendothelial cells in the blood contacting surface of the device for restoringan endothelium at the site of injury. In particular, the drug-coated stentsare for use, for example, in balloon angioplasty procedures for preventing orinhibiting restenosis.
